Probiotics, asthma, food allergies, and IgE
So I am investigating probiotics. I have not ordered TSO yet – but it’s on my radar.
Instead, I am looking into bacteria. In fact, I have L. plantarum on its way as we speak.
Now remember I am not a scientist. Why do I keep saying this – well because I’m aware that I am most likely missing understanding & information. That being said – what resonates with me about bacteria versus parasites is that the later (parasites) will almost always skew the immune system to Th2. And allergy is a Th2 issue. And even while there are regulatory immune markers that induce a ‘tolerance’ of what was previously allergenic, the scales are further tipped towards Th2. Even if we would need to stay on a protocol – probiotics, herbs, parasites… indefinitely, presently, it’s more sustainable for me on other protocols than TSO. And so this becomes point 2 of my argument for bacteria. Again, however, I may change my mind. My son has been itchy, sneezy, and – will get coughy once autumn pollen rises – and this weighs on me. Now that we are off herbs, we must do something.
And so, with some of the research linked below, I’ve decided to move forwards with L. plantarum. In fact, it was L. gasseri that lead me to L. plantarum. I am returning to my original mission – lower IgE. That is my mantra, lower IgE. And, if I may, I view the immune system as somewhat of a scale or seesaw…. so if it’s tilted towards Th2, that means it’s got less to devote to Th1 (the arm most well known for it’s defense against bacteria, viruses, and fungi). Which leads me to add to my mantra:
Lower IgE, Raise IFN gamma
We were on the food allergy herb for awhile. And I must stress, saw some results – less hives for no reason, the ability to eat foods that previously made our mouth itch, like avocadoes (small amounts), less eczema, less sneezing….. And our practitioner did tell us to have expectations that were years out. I mention this because I have found many studies that correlate raising IFN gamma (interfeuron gamma) with increased tolerance and lower IgE levels.
As an example, here is a study with the food allergy herb. Efficacy and immunological actions of FAHF-2 in a murine model of multiple food allergies.It’s interesting, while it is mouse model, that they note in the abstract that interferon-γ levels were elevated in treated mice.
Further studies have correlated with increased interferon-γ levels associated with lower IgE levels.
So here are the strains I’m investigating and studies with the strain & associated immune markers. I’ll update this page as I find studies and info. Also, remember that studies can be skewed, paid for by producers, and manipulated. But I am operating under the assumption that if I can find enough validating a strain – then it’s worth some experimentation.
Oral administration of Lactobacillus plantarum NRIC0380 suppresses IgE production and induces CD4(+)CD25(+)Foxp3(+) cells in vivo. The entire article free. Used L. plantarum in mice, but the difference in IgE levels at 2 week intervals over the 4 week test time is significant.
Immunomodulatory and anti-allergic effects of orally administered Lactobacillus species in ovalbumin-sensitized mice. Full free article. Really makes the case, in mouse model, for L. brevis. Interesting. I hate that the strain is uber specific – Lactobacillus brevis HY7401. Like many strains, impossible to find for sale. Also interesting is that they used 2 specific strains of L. casei – and one increased IgE. This is a mouse model.
We estimated levels of Th1 and Th2 cytokines in OVAstimulated splenocytes. Among Th1 cytokines, IFN-γ inhibits IL-4-derived isotype switching . This cytokine was strongly detected in L1- and L3-administered groups in this study. IL-12 is secreted from APCs, including macrophage and dendritic cells ; it was highly induced in the L3 and L4 groups. Among Th2 cytokines, the most important cytokine is IL-4, because it induces isotype switching to IgE [24, 30]. IL-4 was decreased in the L1 and L4 groups in this study. IL-5 also enhances IL-4-induced IgE production . It was significantly lower in all groups compared with the positive control. IL-6 has a role in IL-4-
dependent IgE synthesis and induces differentiation to antibody-secreting plasma cells . Only the L3 group showed reduced IL-6 levels compared with the positive control. IL-10, known as human cytokine synthesis inhibitory factor, is an anti-inflammatory cytokine, which down-regulates Th1 cytokine expression . In this study, IL-10 was decreased in the L1, L2, and L3 groups. (from the above study)
Bacterial lysates in food allergy prevention. discusses B. breve and S. thermophilus showing slight reduction in food sensitization. It also mentions a product ProSymbioflor containing Escherichia coli plus Enterococcus faecalis – that reduced eczema. This I assume was in infants.
Antiallergic effect of milk fermented with lactic acid bacteria in a murine animal model. again discusses S. thermophilus and the mice fed milk fermented with it having lower IgE levels.
Probiotics reduce the CD34+ hemopoietic precursor cell increased traffic in allergic subjects. 30 days of oral administration of Lactobacillus acidophilus, L. delbrueckii and Streptococcus thermophilus for a total of 1 x 10(9) live bacteria. Circulating CD34+ cell values significantly (p < 0.001) reduced after the treatment. (they state “An increased traffic of circulating CD34+ Hemopoietic Precursors Cells (HPC) is an important feature of systemic allergic inflammation.”). This study discusses a product, I would imagine it was paid for by producer.